Genetic Risk Screening for Cancer
Genetic Risk Screening for Cancer
MyHeritage DNA 360° helps you understand how your DNA may influence your risk for certain cancers. Use these insights to discuss next steps with your healthcare provider.
What your DNA results can help you do
Your DNA results can provide a clearer picture of how your genes may influence your risk for certain cancers, and help you explore appropriate next steps.
Uncover potential risks
Identify genetic variants associated with an increased risk for certain cancers, including risks you may not have known about. These variants may be present even without a known family history of cancer.
Understand what your risk means
Put your results into context and learn what they may mean for your health. Genetic risk is only one part of the picture and does not determine whether you will develop cancer.
Consider your next steps
Share relevant results with your healthcare provider. Together, you can discuss whether lifestyle changes, additional screening, or other preventive measures may be appropriate.
Explore reports on many types of cancer
Explore reports on many types of cancer
Conditions covered include:
Female breast cancer
Hereditary BRCA cancers
Colorectal cancer
Lynch syndrome
Melanoma
Prostate cancer
Pancreatic cancer
PALB2-associated breast cancer
Familial adenomatous polyposis (FAP)
Li-Fraumeni syndrome
Thyroid cancer
Lung cancer
Hereditary Breast and Ovarian Cancer
(BRCA1, BRCA2, PALB2)
Hereditary Breast and Ovarian Cancer (HBOC) is a syndrome caused by pathogenic mutations in the BRCA1, BRCA2 and PALB2 genes. Mutations in these genes increase the risk of breast and ovarian cancer in women, and increased risk of breast and prostate cancer in men.
Juvenile Polyposis Syndrome (JPS)
(BMPR1A, SMAD4)
Juvenile Polyposis Syndrome (JPS) is an autosomal dominant genetic disorder characterized by the development of multiple hamartomatous polyps in the GI tract, predominantly in the colon and rectum. JPS can occur as a result of mutations in the BMPR1A and SMAD4.
Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer)
(MLH1, MSH2, MSH6, PMS2, EPCAM)
Lynch Syndrome, also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC), is an autosomal dominant inherited disorder characterized by a higher risk of colorectal cancer (CRC) and other malignancies, most comonly endometrial cancer. Other sites of cancer include the ovary, stomach, small bowel, pancreatobiliary system, genitourinary system, prostate, brain, breast and skin.
MUTYH-Associated Polyposis
(MUTYH)
MUTYH-Associated Polyposis (MAP) is an autosomal recessive hereditary disorder resulting from biallelic mutations in the MUTYH gene. MUTYH is involved in DNA base excision repair.
Retinoblastoma
(RB1)
Retinoblastoma is a rare, malignant tumor of the retina, primarily affecting young children. It arises due to mutations in the RB1 tumor suppressor gene.
Von Hippel-Lindau syndrome
(VHL)
Von Hippel-Lindau (VHL) disease is a rare autosomal-dominant disorder resulting from mutations in the VHL tumor suppressor gene, leading to the development of benign and malignant tumors, including CNS hemangioblastomas, retinal capillary hemangioblastomas, clear cell renal cell carcinomas (RCCs), pheochromocytomas, pancreatic serous cystadenomas, endolymphatic sac tumors of the middle ear and papillary cystadenomas of the epididymis and broad ligament. Early detection and management are crucial to mitigate complications and improve quality of life.
Female breast cancer
Breast cancer is a disease in which breast cancer cells grow more rapidly than healthy cells. Over time, they can form a lump or tumor.
Prostate cancer
Prostate cancer is a disease in which cancer cells grow more rapidly than healthy cells in a small gland called the prostate. The prostate gland produces seminal fluid that feeds and transports the sperm.
PALB2-associated breast cancer
Cancer is a disease caused by cells that grow out of control, often forming a lump or tumor. Having a PALB2 variant notably increases the lifetime risk to have breast cancer.
Actinic Keratosis
Actinic keratosis causes rough, scaly patches on sun-damaged skin. Primarily triggered by long-term UV exposure, these precancerous skin lesions have the potential to develop into skin cancer if left untreated.
Colorectal cancer
Colorectal cancer is a condition in which cancer cells in the colon (also known as the large intestine) or rectum grow more rapidly than healthy cells. Over time, these cells can form a lump or polyp on the lining of the large intestine.
Multiple Endocrine Neoplasia Type 1
(MEN1)
Multiple Endocrine Neoplasia Type 1 (MEN1) is an autosomal dominant disorder characterized by the development of tumors in multiple endocrine glands, primarily the parathyroid glands, pancreatic islet cells, and anterior pituitary gland. Tumors in the parathyroid glands, occur in the large majority of patients by 50 years of age.
Thyroid cancer
Thyroid cancer is a condition in which cancer cells in the thyroid gland grow more rapidly than healthy cells. This is not to be confused with thyroid nodules, which is also an abnormal growth of cells in the thyroid but are common and rarely require treatment.
Multiple Endocrine Neoplasia Type 2
(RET)
Multiple Endocrine Neoplasia Type 2 (MEN2) is a hereditary syndrome characterized by the development of tumors in multiple endocrine glands, primarily affecting the thyroid, adrenal, and parathyroid glands. Affected patients carry pathogenic variants in the RET gene.
Hereditary Pheochromocytoma/
(SDHA, SDHB, SDHC, SDHD, SDHAF2, MAX, TMEM127)
Hereditary Pheochromocytoma and Paraganglioma (PGL/PCC) syndromes are genetic disorders characterized by the development of tumors arising from neural crest tissue, affecting the adrenal medulla (pheochromocytomas) and extra-adrenal paraganglia (paragangliomas). SDHA, SDHB, SDHC, SDHD, and SDHAF2 cause hereditary paraganglioma-pheochromocytoma syndromes with varying tumor spectra.
Li-Fraumeni Syndrome (LFS)
Li-Fraumeni Syndrome (LFS) is a hereditary cancer predisposition syndrome caused by germline mutations in the TP53 tumor suppressor gene. LFS confers a high lifetime risk of various malignancies throughout one’s lifetime, including breast cancer, sarcomas, brain tumors, and adrenocortical carcinomas, often with childhood onset.
NF2-related schwannomatosis
(NF2)
NF2-related schwannomatosis (formerly neurofibromatosis type 2) is an autosomal dominant inherited disorder caused by pathogenic mutations in the NF2 gene. Patients with NF2 mutations are predisposed to bilateral vestibular schwannomas, and other tumors of the nervous system, including intracranial meningiomas and spinal tumors.
PTEN Hamartoma Tumor Syndromes
(PTEN)
Mutations in the PTEN gene can cause a variety of rare autosomal dominant syndromes that present differently, and are known as PTEN hamartoma tumor syndromes (PHTS). The defining feature of PHTS is the presence of hamartomatous tumors.
Tuberous sclerosis complex
(TSC1, TSC2)
Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder caused by mutations in the TSC1 or TSC2 genes, leading to the development of benign tumors in multiple organs, including the brain, kidneys, heart, eyes, lungs, liver, kidney and skin. TSC varies in severity, even within families.
WT1-related Wilms' tumor
(WT1)
Mutations in the WT1 gene are responsible for about 10-15% of cases of Wilms’ tumor (nephroblastoma), the most common renal and abdominal malignancy in children <15 years old. Wilms tumor affects approximately one child per 10,000 worldwide.
Hereditary BRCA cancers
Cancer is a disease caused by cells that grow out of control, often forming a lump or tumor. Having a BRCA1 or BRCA2 variant significantly increases a woman's lifetime risk of having breast or ovarian cancer.
Squamous Cell Carcinoma
Symptoms of squamous cell carcinoma include persistent, scaly red patches with irregular borders, open sores that may crust or bleed, an elevated growth with a central depression, or warts; these might itch or be painless. Unlike benign skin blemishes, these lesions often do not heal without treatment.
Basal Cell Carcinoma
Unlike other forms of skin cancer, basal cell carcinoma rarely spreads (metastasizes) beyond the original tumor site. However, it can be disfiguring if not treated promptly and can cause considerable destruction and disfigurement by invading surrounding tissues.
Familial Adenomatous Polyposis (FAP)
(APC)
Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease caused by pathogenic variants in the APC gene. FAP is characterized by the development of numerous adenomatous polyps in the colon and rectum, significantly increasing the risk of colorectal cancer, as well as upper intestinal and extraintestinal tumors.
Melanoma
Melanoma is a condition where cancer cells form in melanocytes, the skin cells that produce color, and grow more rapidly than healthy cells. Melanoma may start in the skin or in the mucous membranes, the moist layers of tissue that cover things like the inside of the nose.
Peutz-Jeghers syndrome (PJS)
(STK11)
Peutz-Jeghers syndrome (PJS) is an autosomal dominant syndrome caused by pathogenic mutations in the tumor suppressor gene STK11. It is characterized by multiple hamartomatous polyps in the GI tract, mucocutaneous pigmentation, and an increased risk of GI and non-GI cancer.
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